{"product_id":"sema4a-polyclonal-antibody-e-ab-15382","title":"SEMA4A Polyclonal Antibody - E-AB-15382","description":"\u003cp\u003eSEMA4A Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-15382-60, E-AB-15382-120, E-AB-15382-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SEMA4A\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CORD10; RP11 54H19 2; RP35; SEM4A; Sema B; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain 4A; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4A; Sema domain; immunoglobulin domain (Ig); transmembrane domain (TM) and short cytoplasmic domain; (semaphorin); Sema4a; SEMAB; Semaphorin 4A precursor; Semaphorin B; Semaphorin-4A; Semaphorin-B; SEMB\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cardiovascular, Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9H3S1\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.8 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of human SEMA4A\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:30-1:150\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"200μL","offer_id":43124192772275,"sku":"E-AB-15382-200","price":558.6,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43124192805043,"sku":"E-AB-15382-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"60μL","offer_id":43124192837811,"sku":"E-AB-15382-60","price":200.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_602ee8d0-cbbd-40d8-a4f7-546c71b8318e.png?v=1709725456","url":"https:\/\/afsbio.com\/products\/sema4a-polyclonal-antibody-e-ab-15382","provider":"AFSBio Inc.","version":"1.0","type":"link"}