{"product_id":"septin-2-l136-polyclonal-antibody-bs3936","title":"Septin 2 (L136) Polyclonal Antibody-BS3936","description":"\u003cp\u003eSeptin 2 (L136) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS3936-50, BS3936-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q15019\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: The transcriptional regulation of all septins is complex, resulting in alternatively spliced variants. At least three septins (Septin 1, 2 and 4) are associated with a Tau-based paired helical filament core and may contribute to the formation of neurofibrillary tangle as integral constituents of paired helical filaments. Septin 3 (G-Septin), a GTPbinding protein, is highly expressed in brain and is regulated by protein kinase G in neurons. The human SEPT4 (H5\/PNUTL2\/CDCrREL-2) gene encodes ARTS (for apoptosis-related protein in the TGF β signaling pathway), which is expressed in many cells and acts to enhance cell death induced by TGF β or, to a lesser extent, by other apoptotic agents. ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs.\u003c\/p\u003e \n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Septin 2 (L136) polyclonal antibody detects endogenous levels of Septin 2 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of SEPT2 pAb at 1:1000 dilution\u003cbr\u003e\nLane1:HepG2 whole cell lysate(40ug)\u003cbr\u003e\nLane2:HEK293T whole cell lysate(40ug)\u003cbr\u003e\nLane3:AML-12 whole cell lysate(40ug)\u003cbr\u003e\nLane4:PC12 whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 45 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: DIFF6; hNEDD5; KIAA0158; Neural precursor cell expressed developmentally down regulated protein 5; Pnutl3; Protein NEDD5; SEPT2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 108-157 of Human Septin 2.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42910470471859,"sku":"BS3936-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42910470504627,"sku":"BS3936-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_33b4cdc7-9220-4ca0-bfb7-3dfd47fec36d.jpg?v=1703093042","url":"https:\/\/afsbio.com\/products\/septin-2-l136-polyclonal-antibody-bs3936","provider":"AFSBio Inc.","version":"1.0","type":"link"}