{"product_id":"sf3b3-polyclonal-antibody-bs70723","title":"SF3B3 Polyclonal Antibody-BS70723","description":"\u003cp\u003eSF3B3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS70723-50, BS70723-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q15393\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB\t1:500 - 1:2000\u003cbr\u003e\nIHC\t1:50 - 1:200\u003cbr\u003e\nIF\t1:50 - 1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b\/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: SF3B3 polyclonal antibody detects endogenous levels of SF3B3 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 136 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of extracts of mouse tissues, using SF3B3 antibody., Immunohistochemistry of paraffin-embedded rat brain using SF3B3 antibody at dilution of 1:200 (40x lens)., Immunohistochemistry of paraffin-embedded rat kidney using SF3B3 antibody at dilution of 1:200 (40x lens).\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: RSE1; SAP130; SF3b130; STAF130;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant protein of human SF3B3.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42997580890291,"sku":"BS70723-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42997580923059,"sku":"BS70723-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_4f2d025d-461f-4e91-b240-0b167fba79fd.jpg?v=1706270671","url":"https:\/\/afsbio.com\/products\/sf3b3-polyclonal-antibody-bs70723","provider":"AFSBio Inc.","version":"1.0","type":"link"}