{"product_id":"sgk-s422-polyclonal-antibody-ap0586","title":"SGK (S422) Polyclonal Antibody - AP0586","description":"\u003cp\u003eSGK (S422) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: AP0586-50, AP0586-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Serum and glucocorticoid-inducible kinase (SGK) is a serine\/threonine kinase closely related to Akt. SGK is rapidly induced in response to a variety of stimμli, including serum, glucocorticoid, follicle stimμlating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways. Induction and activation of SGK has been implicated in activating the modμlation of anti-apoptotic and cell cycle regμlation. SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regμlation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK is negatively regμlated by ubiquitination and proteasome degradation.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Serine\/threonine-protein kinase Sgk1, Serum\/glucocorticoid-regμlated kinase 1, SGK1, SGK, Serine\/threonine-protein kinase Sgk2Serum\/glucocorticoid-regμlated kinase 2, SGK2, Serine\/threonine-protein kinase Sgk3, Cytokine-independent survival kinase, Serum\/glucocorticoid-regμlated kinase 3, Serum\/glucocorticoid-regμlated kinase-like, SGK3, CISK, SGKL\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human SGK.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:2000~1:5000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: SGK (S422) polyclonal antibody detects endogenous levels of SGK protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 58 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: MTOR signaling,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: O00141\/Q9HBY8\/Q96BR1\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946176110771,"sku":"AP0586-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946176143539,"sku":"AP0586-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/sgk-s422-polyclonal-antibody-ap0586","provider":"AFSBio Inc.","version":"1.0","type":"link"}