{"product_id":"sgk1-monoclonal-antibody-e-ab-22207","title":"SGK1 Monoclonal Antibody - E-AB-22207","description":"\u003cp\u003eSGK1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-22207-60, E-AB-22207-120, E-AB-22207-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SGK1 Mouse (4D12)\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: OTTHUMP00000017247; Serine\/threonine protein kinase SGK; Serine\/threonine protein kinase Sgk1; Serine\/threonine-protein kinase Sgk1; Serum and glucocorticoid regulated kinase; Serum\/glucocorticoid regulated kinase 1; Serum\/glucocorticoid regulated kinase; Serum\/glucocorticoid-regulated kinase 1; SGK 1; SGK; SGK1; Sgk1 variant i3; SGK1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Developmental Biology, Signal Transduction, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC-p\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone No.: Clone:4D12\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O00141\u003c\/p\u003e\n\n\u003cp\u003eBackground: Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3\/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide of SGK1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Protein A purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:100-200\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43135924994227,"sku":"E-AB-22207-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43135925026995,"sku":"E-AB-22207-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43135925059763,"sku":"E-AB-22207-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ecd0acc9-70a6-4471-ad9c-1a6f10b5e92a.png?v=1709986595","url":"https:\/\/afsbio.com\/products\/sgk1-monoclonal-antibody-e-ab-22207","provider":"AFSBio Inc.","version":"1.0","type":"link"}