{"product_id":"sh21a-polyclonal-antibody-bt-ap14181","title":"SH21A Polyclonal Antibody - BT-AP14181","description":"\u003cp\u003eSH21A Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14181-20, BT-AP14181-50, BT-AP14181-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been f\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular; Immunology\u003c\/p\u003e \n\n\u003cp\u003eTarget Protein: SH2D1A\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: SH2 domain-containing protein 1A\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O60880; Mouse: O88890; Rat: B2RZ59\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SH2 domain-containing protein 1A;Duncan disease SH2-protein;Signaling lymphocytic activation molecule-associated protein;SLAM-associated protein;T-cell signal transduction molecule SAP\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4068\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239345676467,"sku":"BT-AP14181-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239345709235,"sku":"BT-AP14181-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239345742003,"sku":"BT-AP14181-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_efcf65d3-6f76-4721-b305-c1dab289e938.png?v=1769393324","url":"https:\/\/afsbio.com\/products\/sh21a-polyclonal-antibody-bt-ap14181","provider":"AFSBio Inc.","version":"1.0","type":"link"}