{"product_id":"shank2-polyclonal-antibody-bs62481","title":"SHANK2 Polyclonal Antibody-BS62481","description":"\u003cp\u003eSHANK2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS62481-50, BS62481-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9UPX8\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:500~1:1000 IHC:1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: The SHANK family proteins, also known as proline-rich synapse-associated proteins, consist of SHANK1, SHANK2, and SHANK3. SHANK proteins act as scaffolds at the neuronal post-synaptic density (PSD), where they play a critical role in PSD assembly of excitatory synapses during development. While recruitment of SHANK proteins to the synapse is independent of their interaction with Homer, proper synaptic targeting of SHANK1 is mediated by interactions between its PDZ domain and PSD proteins. At the synapse, SHANK proteins interact with NMDA receptors and metabotropic glutamate receptor complexes. Research studies have proposed the involvement of SHANK proteins in autism and neurodegenerative diseases.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: SHANK2 polyclonal antibody detects endogenous levels of SHANK2 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of SHANK2 polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLaneA:A549 whole cell lysate\u003cbr\u003e\nLaneB:HCT116 whole cell lysate\u003cbr\u003e\nLaneC:CT26 whole cell lysate\u003cbr\u003e\nLaneD:PC12 whole cell lysate\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 135 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: SH3 and multiple ankyrin repeat domains protein 2; Shank2; Cortactin-binding protein 1; CortBP1; Proline-rich synapse-associated protein 1; SHANK2; CORTBP1; KIAA1022; PROSAP1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human SHANK2.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42910447009971,"sku":"BS62481-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42910447042739,"sku":"BS62481-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_89f2b2b6-a1ee-4a64-a72f-78fed09d61dd.jpg?v=1703092561","url":"https:\/\/afsbio.com\/products\/shank2-polyclonal-antibody-bs62481","provider":"AFSBio Inc.","version":"1.0","type":"link"}