{"product_id":"shc-phospho-tyr317-rabbit-polyclonal-antibody-bt-ap04727","title":"Shc (Phospho-Tyr317) Rabbit Polyclonal Antibody - BT-AP04727","description":"\u003cp\u003eShc (Phospho-Tyr317) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP04727-20, BT-AP04727-50, BT-AP04727-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways| the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms| p52Shc and p46Shc| link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2\/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms| p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Neuroscience; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SHC1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Shc\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P29353; Mouse: P98083; Rat: Q5M824\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Shc;Tyr317; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1; SH2 domain protein C1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 6464; Mouse: 20416; Rat: 85385\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239021895859,"sku":"BT-AP04727-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239021928627,"sku":"BT-AP04727-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239021961395,"sku":"BT-AP04727-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c498bcf3-7f57-4625-9a42-54b37d467ff1.png?v=1769388033","url":"https:\/\/afsbio.com\/products\/shc-phospho-tyr317-rabbit-polyclonal-antibody-bt-ap04727","provider":"AFSBio Inc.","version":"1.0","type":"link"}