{"product_id":"shc2-polyclonal-antibody-bs65264","title":"SHC2 Polyclonal Antibody-BS65264","description":"\u003cp\u003eSHC2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65264-50, BS65264-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P98077\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB,ELISA\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eBackground: domain:The PID domain mediates binding to the TrkA receptor.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Sck Polyclonal Antibody detects endogenous levels of Sck protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of lysates from Jurkat cells, using SHC2 Antibody. The lane on the right is blocked with the synthesized peptide.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 59 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42908766830771,"sku":"BS65264-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42908766863539,"sku":"BS65264-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_0535280f-a8e8-4b9d-8198-bba5e5373926.jpg?v=1703006824","url":"https:\/\/afsbio.com\/products\/shc2-polyclonal-antibody-bs65264","provider":"AFSBio Inc.","version":"1.0","type":"link"}