{"product_id":"shp-2-phospho-tyr542-rabbit-polyclonal-antibody-bt-ap12655","title":"SHP-2 (Phospho-Tyr542) Rabbit Polyclonal Antibody - BT-AP12655","description":"\u003cp\u003eSHP-2 (Phospho-Tyr542) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP12655-20, BT-AP12655-50, BT-AP12655-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth| differentiation| mitotic cycle| and oncogenic transformation. This PTP contains two tandem Src homology-2 domains| which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions| such as mitogenic activation| metabolic control| transcription regulation| and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Neuroscience; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PTPN11\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: SHP-2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q06124; Mouse: P35235; Rat: P41499\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SHP-2;Tyr542; Tyrosine-protein phosphatase non-receptor type 11; EC 3.1.3.48; Protein-tyrosine phosphatase 1D; PTP-1D; Protein-tyrosine phosphatase 2C; PTP-2C; SH-PTP2; SHP-2; Shp2; SH-PTP3\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5781; Mouse: 19247; Rat: 25622\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239022321843,"sku":"BT-AP12655-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239022354611,"sku":"BT-AP12655-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239022387379,"sku":"BT-AP12655-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c2ec7b7c-cc10-4e3c-ac2c-6163bc69d68b.png?v=1769388038","url":"https:\/\/afsbio.com\/products\/shp-2-phospho-tyr542-rabbit-polyclonal-antibody-bt-ap12655","provider":"AFSBio Inc.","version":"1.0","type":"link"}