{"product_id":"siglec8-monoclonal-antibody-bt-mca4447","title":"SIGLEC8 Monoclonal Antibody - BT-MCA4447","description":"\u003cp\u003eSIGLEC8 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4447-50, BT-MCA4447-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983])\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SIGLEC8\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 1A5B9\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2b\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: SIGLEC8\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human SIGLEC8 (AA: extra 17-216) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 54kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q9NYZ4\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SAF2, SIGLEC-8, SIGLEC8L\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 27181\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238390980787,"sku":"BT-MCA4447-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238391013555,"sku":"BT-MCA4447-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_41ee0e68-fdb7-4937-9395-c050e2175f17.png?v=1769379798","url":"https:\/\/afsbio.com\/products\/siglec8-monoclonal-antibody-bt-mca4447","provider":"AFSBio Inc.","version":"1.0","type":"link"}