{"product_id":"sik1-polyclonal-antibody-bt-ap14226","title":"SIK1 Polyclonal Antibody - BT-AP14226","description":"\u003cp\u003eSIK1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14226-20, BT-AP14226-50, BT-AP14226-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,Transient role during the earliest stages of myocardial cell differentiation and\/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and\/or differentiation. Potential role in G2\/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the protein kinase superfamily. CAMK Ser\/Thr protein kinase family. AMPK subfamily.,Contains 1 protein kinase domain.,Contains 1 UBA domain.,subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.,subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182.,\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular; Cell biology; Epigenetics and nuclear signaling; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SIK1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Serine\/threonine-protein kinase SIK1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P57059; Mouse: Q60670; Rat: Q9R1U5\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Serine\/threonine-protein kinase SIK1;EC 2.7.11.1;Salt-inducible kinase 1;SIK-1;Serine\/threonine-protein kinase SNF1-like kinase 1;Serine\/threonine-protein kinase SNF1LK\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 150094\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239347937459,"sku":"BT-AP14226-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239347970227,"sku":"BT-AP14226-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239348002995,"sku":"BT-AP14226-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5babb4a2-32dc-429a-921a-c10ac3ce7ae4.png?v=1769393352","url":"https:\/\/afsbio.com\/products\/sik1-polyclonal-antibody-bt-ap14226","provider":"AFSBio Inc.","version":"1.0","type":"link"}