{"product_id":"sirt5-rabbit-polyclonal-antibody-ra36915","title":"SIRT5 Rabbit Polyclonal Antibody - RA36915","description":"\u003cp\u003eSIRT5 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA36915-50, RA36915-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically\u003cbr\u003e\nremoves malonyl, succinyl and glutaryl groups on target proteins . Activates CPS1 and\u003cbr\u003e\ncontributes to the regulation of blood ammonia levels during prolonged fasting: acts by\u003cbr\u003e\nmediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting . Activates SOD1 by mediating its\u003cbr\u003e\ndesuccinylation, leading to reduced reactive oxygen species . Activates SHMT2 by\u003cbr\u003e\nmediating its desuccinylation . Modulates ketogenesis through the desuccinylation and\u003cbr\u003e\nactivation of HMGCS2 (By similarity) . Has weak NAD-dependent protein deacetylase\u003cbr\u003e\nactivity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1:500-2000\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: SIRT5 SIR2L5\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 23408\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 34\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9NXA8\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45122496626867,"sku":"RA36915-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45122496659635,"sku":"RA36915-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_61a662b7-825f-470a-89d9-07ed1cb67609.png?v=1773343293","url":"https:\/\/afsbio.com\/products\/sirt5-rabbit-polyclonal-antibody-ra36915","provider":"AFSBio Inc.","version":"1.0","type":"link"}