{"product_id":"siva-rabbit-polyclonal-antibody-es10565","title":"SIVA Rabbit Polyclonal Antibody - ES10565","description":"\u003cp\u003eSIVA Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES10565-50, ES10565-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse,\u003c\/p\u003e \n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein AA range: 1-50\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: SIVA\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: SIVA Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Ubiquitous, Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 19kD\u003c\/p\u003e\n\n\u003cp\u003eFields: p53 signaling pathway\u003c\/p\u003e\n\n\u003cp\u003eFunction: Cofactor: Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions\u003cbr\u003e\nFunction: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis\u003cbr\u003e\npharmaceutical: Could be used as a potentiator of cisplatin-based chemotherapy. Enhances cisplatin-mediated apoptosis, even under conditions where cisplatin resistance occurs due to elevated levels of BCL2 or BCL2L1\u003cbr\u003e\nPTM: Phosphorylated by ABL2\/ARG in response to oxidative stress\u003cbr\u003e\nSubcellular Location: In the nucleus, accumulates in dot-like structures\u003cbr\u003e\nSubunit: Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2\/PMP22. Binds to the C-terminus of TNFRSF18\/GITR. Isoform 1 binds to BCL2L1\/BCLX isoform Bcl-x(L) but not to BAX. Binds to capsid protein VP2 from coxsackievirus B3. Binding of SIVA1 to CD27 can be blocked by VP2\u003cbr\u003e\nt\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm Nucleus In the nucleus, accumulates in dot-like structures\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: SIVA1 SIVA\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Apoptosis regulatory protein Siva (CD27-binding protein) (CD27BP)\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: O54926\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P59692\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314299162803,"sku":"ES10565-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314299195571,"sku":"ES10565-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/siva-rabbit-polyclonal-antibody-es10565","provider":"AFSBio Inc.","version":"1.0","type":"link"}