{"product_id":"skil-polyclonal-antibody-e-ab-67710","title":"SKIL Polyclonal Antibody - E-AB-67710","description":"\u003cp\u003eSKIL Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-67710-60, E-AB-67710-120, E-AB-67710-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SKIL\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: SKIL; SNO; SnoA; SnoI; SnoN\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P12757\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human SKIL\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 44kDa\/46kDa\/71kDa\/74kDa\/76kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 75KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146454007987,"sku":"E-AB-67710-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146454040755,"sku":"E-AB-67710-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146454073523,"sku":"E-AB-67710-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_dec546c5-b5ee-4c68-a2cb-e8e392b1e079.png?v=1710295846","url":"https:\/\/afsbio.com\/products\/skil-polyclonal-antibody-e-ab-67710","provider":"AFSBio Inc.","version":"1.0","type":"link"}