{"product_id":"slam-rabbit-pab-es4009","title":"SLAM rabbit pAb - ES4009","description":"\u003cp\u003eSLAM rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4009-50, ES4009-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: domain:The most membrane-proximal SH2-binding motif interacts with SH2 domain of SH2D1A and does not need to be phosphorylated on tyrosine residues., function:High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates., PTM:Phosphorylated by FYN., similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain., similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain., subcellular location:Present on the surface of B-cells and T-cells., subunit:Its cytoplasmic domain interacts with SH2 domain protein 1A (SH2D1A), and with PTPN11. Interacts with INPP5D\/SHIP1. Binds to Measles virus HN protein and acts as a receptor for this virus., tissue specificity:Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes, and a proportion of B-cells, and is rapidely induced on naive T-cells after activation.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: SLAMF1; SLAM; Signaling lymphocytic activation molecule; CDw150; IPO-3; CD150\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. IHC-p: 1:100-300 ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human SLAMF1. AA range:81-130\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 37kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 6504\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q13291\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell membrane; Single-pass type I membrane protein. Present on the surface of B-cells and T-cells. Located at the plasma membrane contacts between neighboring T-cells (PubMed:11806999).; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane. Overexpressed isoform 4 is detected on the cell surface. In glioma cell lines endogenuous isoform 4 is detetced predominantly in the cytoplasm and colocalized with endoplasmic reticulum and Golgi markers.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202169364659,"sku":"ES4009-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202169397427,"sku":"ES4009-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_d3d61b48-14de-404e-bead-3dc4565e123e.png?v=1767123504","url":"https:\/\/afsbio.com\/products\/slam-rabbit-pab-es4009","provider":"AFSBio Inc.","version":"1.0","type":"link"}