{"product_id":"slamf7-polyclonal-antibody-e-ab-90741","title":"SLAMF7 Polyclonal Antibody - E-AB-90741","description":"\u003cp\u003eSLAMF7 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-90741-60, E-AB-90741-120, E-AB-90741-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SLAMF7\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: SLAMF7; 19A; CD319; CRACC; CS1\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9NQ25\u003c\/p\u003e\n\n\u003cp\u003eBackground: SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed on the surface of NK cells, CD8+ T cells, activated B cells, and mature dendritic cells but not in promyelocytic, B-cell lines, or T-cell lines. In human NK cells, activated SLAMF7 transmits signals following association with the adaptor protein EAT-2 . In the absence of EAT-2, SLAMF7 potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human SLAMF7\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 17kDa\/21kDa\/22kDa\/25kDa\/32kDa\/37kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 25-70KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43148747407539,"sku":"E-AB-90741-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43148747440307,"sku":"E-AB-90741-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43148747473075,"sku":"E-AB-90741-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_273282d5-2578-4348-b689-40992b98bc56.png?v=1710329183","url":"https:\/\/afsbio.com\/products\/slamf7-polyclonal-antibody-e-ab-90741","provider":"AFSBio Inc.","version":"1.0","type":"link"}