{"product_id":"slk-polyclonal-antibody-bs2137","title":"SLK Polyclonal Antibody-BS2137","description":"\u003cp\u003eSLK Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2137-50, BS2137-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9H2G2\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: SLK (Ste20-like kinase), also known as STK2 (serine\/threonine protein kinase 2) or se20-9, is a member of the serine\/threonine kinase subfamily, Ste20. This subfamily is comprised of several mammalian kinases which exhibit sequence similarity to the Saccharomyces cerevisiae serine\/threonine kinase Ste20, a protein involved in relaying signals from G protein-coupled receptors to cytosolic MAP kinase cascades. Members of this subfamily include KHS, GLK, YSK1, HPK1, Krs-1, Krs-2, GC kinase, HGK and SLK. SLK is a ubiquitously expressed protein that localizes to the cytoplasm and contains an N-terminal protein kinase domain, a central coiled-coil domain and a C-terminal ATH domain. SLK is activated through cleavage by caspase-3. SLK indirectly associates with microtubules and plays an important role in cellular stress, cell motility, cell death and cytoskeletal dynamics.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: SLK polyclonal antibody detects endogenous levels of SLK protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of SLK polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane1:HCT116 whole cell lysate(40ug)\u003cbr\u003e\nLane2:THP-1 whole cell lysate(20ug)\u003cbr\u003e\nLane3:The Heart tissue lysate of Rat(40ug)\u003cbr\u003e\nLane4:The Heart tissue lysate of Mouse(40ug)\u003cbr\u003e\nLane5:LOVO whole cell lysate(20ug)\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 220 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: STE20-like serine\/threonine-protein kinase; STE20-like kinase; hSLK; CTCL tumor antigen se20-9; STE20-related serine\/threonine-protein kinase; STE20-related kinase; Serine\/threonine-protein kinase 2; SLK; KIAA0204; STK2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding  Human SLK.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42910478762163,"sku":"BS2137-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42910478794931,"sku":"BS2137-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_ca747693-ca65-40b9-9b3b-9f30147ac973.jpg?v=1703093246","url":"https:\/\/afsbio.com\/products\/slk-polyclonal-antibody-bs2137","provider":"AFSBio Inc.","version":"1.0","type":"link"}