{"product_id":"smad2-phospho-ser465-467-rabbit-polyclonal-antibody-bt-ap12682","title":"Smad2 (Phospho-Ser465\/467) Rabbit Polyclonal Antibody - BT-AP12682","description":"\u003cp\u003eSmad2 (Phospho-Ser465\/467) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP12682-20, BT-AP12682-50, BT-AP12682-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the SMAD| a family of proteins similar to the gene products of the Drosophila gene andapos;mothers against decapentaplegicandapos; (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta| and thus regulates multiple cellular processes| such as cell proliferation| apoptosis| and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal| this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Signal transduction; Cancer; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SMAD2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Smad2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q15796; Mouse: Q62432; Rat: O70436\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Smad2;Ser465\/467; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4087; Mouse: 17126; Rat: 29357\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239023108275,"sku":"BT-AP12682-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239023141043,"sku":"BT-AP12682-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239023173811,"sku":"BT-AP12682-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f53f7755-e515-4abd-ae52-c9b274f14033.png?v=1769388047","url":"https:\/\/afsbio.com\/products\/smad2-phospho-ser465-467-rabbit-polyclonal-antibody-bt-ap12682","provider":"AFSBio Inc.","version":"1.0","type":"link"}