{"product_id":"smad3-monoclonal-antibody-mb65975","title":"SMAD3 Monoclonal Antibody - MB65975","description":"\u003cp\u003eSMAD3 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB65975-50, MB65975-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Receptor-regμlated SMAD (R-SMAD) that is an intracellμlar signal transducer and transcriptional modμlator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regμlated by TGF-beta and, on formation of the SMAD3\/SMAD4 complex, activates transcription. Also can form a SMAD3\/SMAD4\/JUN\/FOS complex at the AP-1\/SMAD site to regμlate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modμlating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regμlator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regμlates PDPK1 kinase activity by stimμlating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regμlator.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: MADH3, Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein corresponding to human SMAD3.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/1000 - 1\/2000), IHC (1\/100 - 1\/200)\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of SMAD3 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 52 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Tumor Angiogenesis, Cell Cycle Control G1 S Checkpoint, TGFβ Smad signaling,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P84022\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946394214579,"sku":"MB65975-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946394247347,"sku":"MB65975-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/smad3-monoclonal-antibody-mb65975","provider":"AFSBio Inc.","version":"1.0","type":"link"}