{"product_id":"smad4-monoclonal-antibody-bt-mca1136","title":"Smad4 Monoclonal Antibody - BT-MCA1136","description":"\u003cp\u003eSmad4 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA1136-50, BT-MCA1136-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction; Epigenetics and nuclear signaling; Cancer; Stem cells; Metabolism; Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SMAD4\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF, ICC, FCM, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Mothers against decapentaplegic homolog 4\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q13485; Mouse: P97471\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SMAD4; DPC4; MADH4; Mothers against decapentaplegic homolog 4; MAD homolog 4; Mothers against DPP homolog 4; Deletion target in pancreatic carcinoma 4; SMAD family member 4; SMAD 4; Smad4; hSMAD4\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4089\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238755721395,"sku":"BT-MCA1136-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238755754163,"sku":"BT-MCA1136-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_50d6df8c-b33d-48bf-9010-384b2b5d775d.png?v=1769384419","url":"https:\/\/afsbio.com\/products\/smad4-monoclonal-antibody-bt-mca1136","provider":"AFSBio Inc.","version":"1.0","type":"link"}