{"product_id":"smg7-polyclonal-antibody-e-ab-65287","title":"SMG7 Polyclonal Antibody - E-AB-65287","description":"\u003cp\u003eSMG7 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-65287-60, E-AB-65287-120, E-AB-65287-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SMG7\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: SMG7; C1orf16; EST1C; SGA56M\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q92540\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human SMG7 (NP_963863.2).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:200-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 122kDa\/127kDa\/131kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 127kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146364354739,"sku":"E-AB-65287-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146364387507,"sku":"E-AB-65287-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146364420275,"sku":"E-AB-65287-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8d3bd00f-b37a-44d0-bf85-08aee902a25b.png?v=1710294327","url":"https:\/\/afsbio.com\/products\/smg7-polyclonal-antibody-e-ab-65287","provider":"AFSBio Inc.","version":"1.0","type":"link"}