{"product_id":"snai1-monoclonal-antibody-bt-mca4792","title":"SNAI1 Monoclonal Antibody - BT-MCA4792","description":"\u003cp\u003eSNAI1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4792-50, BT-MCA4792-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SNAI1\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6D2\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: SNAI1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human SNAI1 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 29kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: O95863\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SNA, SNAH, SLUGH2, dJ710H13.1, SNAI1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6615\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238426009779,"sku":"BT-MCA4792-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238426042547,"sku":"BT-MCA4792-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_791d1522-f08d-4e34-9957-26720a1f5523.png?v=1769380603","url":"https:\/\/afsbio.com\/products\/snai1-monoclonal-antibody-bt-mca4792","provider":"AFSBio Inc.","version":"1.0","type":"link"}