{"product_id":"snon-polyclonal-antibody-bt-ap08426","title":"SnoN Polyclonal Antibody - BT-AP08426","description":"\u003cp\u003eSnoN Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP08426-20, BT-AP08426-50, BT-AP08426-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Ski-like protein encoded by SKIL is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SKIL\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: SnoN Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 77004\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P12757; Mouse: Q60665\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 6498; Mouse: 20482\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239913939123,"sku":"BT-AP08426-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239913971891,"sku":"BT-AP08426-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239914004659,"sku":"BT-AP08426-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_fcbacf14-af6f-4ede-b402-973bbf3a597d.png?v=1769400850","url":"https:\/\/afsbio.com\/products\/snon-polyclonal-antibody-bt-ap08426","provider":"AFSBio Inc.","version":"1.0","type":"link"}