{"product_id":"sode-rabbit-polyclonal-antibody-es13022","title":"SODE Rabbit Polyclonal Antibody - ES13022","description":"\u003cp\u003eSODE Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES13022-50, ES13022-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA, IHC\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human SODE AA range: 67-117\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: SODE\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of SODE at Human\/Mouse\/Rat\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, IHC-p 1:50-300, ELISA 2000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Expressed in blood vessels, heart, lung, kidney and placenta, Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid,\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 26kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: 2 superoxide + 2 H(+) = O(2) + H(2)O(2)\u003cbr\u003e\nCofactor: Binds 1 copper ion per subunit\u003cbr\u003e\nCofactor: Binds 1 zinc ion per subunit\u003cbr\u003e\nFunction: Destroys radicals which are normally produced within the cells and which are toxic to biological systems\u003cbr\u003e\nFunction: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen\u003cbr\u003e\nOnline Information: Superoxide dismutase entry,polymorphism: The variant Gly-231 which is found in about 2.2% of individual displays a 10-fold increased plasma EC-SOD content due to reduced heparin-binding affinity and thus the impairment of its binding ability to endothelial cell surface\u003cbr\u003e\nSimilarity: Belongs to the Cu-Zn superoxide dismutase family\u003cbr\u003e\nSubcellular Location: 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the v\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Secreted, extracellular space Golgi apparatus, trans-Golgi network 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: SOD3\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: SODE\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 20657\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: O09164\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 25352\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q08420\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315026612403,"sku":"ES13022-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315026645171,"sku":"ES13022-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/sode-rabbit-polyclonal-antibody-es13022","provider":"AFSBio Inc.","version":"1.0","type":"link"}