{"product_id":"sorbitol-dehydrogenase-polyclonal-antibody-e-ab-93273","title":"Sorbitol Dehydrogenase Polyclonal Antibody - E-AB-93273","description":"\u003cp\u003eSorbitol Dehydrogenase Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-93273-60, E-AB-93273-120, E-AB-93273-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Sorbitol Dehydrogenase\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: SORD; HEL-S-95n; SORD1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Metabolism, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q00796\u003c\/p\u003e\n\n\u003cp\u003eBackground: Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human Sorbitol Dehydrogenase\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 10kDa\/38kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 38KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146689544371,"sku":"E-AB-93273-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146689577139,"sku":"E-AB-93273-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146689609907,"sku":"E-AB-93273-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_28333047-8766-49ef-930a-cb021c504ebd.png?v=1710300204","url":"https:\/\/afsbio.com\/products\/sorbitol-dehydrogenase-polyclonal-antibody-e-ab-93273","provider":"AFSBio Inc.","version":"1.0","type":"link"}