{"product_id":"sorl1-monoclonal-antibody-bt-mca4098","title":"SORL1 Monoclonal Antibody - BT-MCA4098","description":"\u003cp\u003eSORL1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4098-50, BT-MCA4098-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction, Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SORL1\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 7D7B11\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: SORL1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of SORL1 (aa2159-2214) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q92673\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SORL1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6653\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238368469171,"sku":"BT-MCA4098-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238368501939,"sku":"BT-MCA4098-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_1197429e-52bd-44f8-b231-b9e3bd6ff1e4.png?v=1769379273","url":"https:\/\/afsbio.com\/products\/sorl1-monoclonal-antibody-bt-mca4098","provider":"AFSBio Inc.","version":"1.0","type":"link"}