{"product_id":"sox2-monoclonal-antibody-mb66993","title":"SOX2 Monoclonal Antibody - MB66993","description":"\u003cp\u003eSOX2 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66993-50, MB66993-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Embryonic stem cells (ESC) derived from the inner cell mass of the blastocyst are unique in their pluripotent capacity and potential for self-renewal . Research studies demonstrate that a set of transcription factors that includes Oct-4, Sox2, and Nanog forms a transcriptional network that maintains cells in a pluripotent state . Chromatin immunoprecipitation experiments show that Sox2 and Oct-4 bind to thousands of gene regμlatory sites, many of which regμlate cell pluripotency and early embryonic development . siRNA knockdown of either Sox2 or Oct-4 resμlts in loss of pluripotency . Induced overexpression of Oct-4 and Sox2, along with additional transcription factors Klf4 and c-Myc, can reprogram both mouse and human somatic cells to a pluripotent state . Additional evidence demonstrates that Sox2 is also present in adμlt mμltipotent progenitors that give rise to some adμlt epithelial tissues, including several glands, the glandμlar stomach, testes, and cervix. Sox2 is thought to regμlate target gene expression important for survival and regeneration of these tissues .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\/ICC, FC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Transcription factor SOX-2\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human SOX2. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000), IHC (1\/50 - 1\/200), IF\/ICC (1\/10 - 1\/50), FC (1\/10 - 1\/50)\u003c\/p\u003e\n\n\u003cp\u003ePurification: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of SOX2 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 35 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: ESC Pluripotency and Differentiation Signaling Pathway.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P48431\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946427474099,"sku":"MB66993-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946427506867,"sku":"MB66993-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/sox2-monoclonal-antibody-mb66993","provider":"AFSBio Inc.","version":"1.0","type":"link"}