{"product_id":"sp1-phospho-thr453-rabbit-pab-es7256","title":"Sp1 (phospho Thr453) rabbit pAb - ES7256","description":"\u003cp\u003eSp1 (phospho Thr453) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES7256-50, ES7256-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: SP1; TSFP1; Transcription factor Sp1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human SP1 around the phosphorylation site of Thr453. AA range:421-470\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 90kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 6667\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P08047\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Cytoplasm. Nuclear location is governed by glycosylated\/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202334515379,"sku":"ES7256-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202334548147,"sku":"ES7256-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_c7ce203d-2c92-419b-bccf-bff67e3a4576.png?v=1767126840","url":"https:\/\/afsbio.com\/products\/sp1-phospho-thr453-rabbit-pab-es7256","provider":"AFSBio Inc.","version":"1.0","type":"link"}