{"product_id":"sphk1-polyclonal-antibody-bt-ap14420","title":"SPHK1 Polyclonal Antibody - BT-AP14420","description":"\u003cp\u003eSPHK1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14420-20, BT-AP14420-50, BT-AP14420-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Signal transduction; Metabolism; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SPHK1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Sphingosine kinase 1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9NYA1; Mouse: Q8CI15; Rat: Q91V26\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Sphingosine kinase 1;SK 1;SPK 1;EC 2.7.1.91\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 8877\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239361503411,"sku":"BT-AP14420-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239361536179,"sku":"BT-AP14420-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239361568947,"sku":"BT-AP14420-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_dbd7b40b-ca70-455a-8a3b-d329a2bf7687.png?v=1769393494","url":"https:\/\/afsbio.com\/products\/sphk1-polyclonal-antibody-bt-ap14420","provider":"AFSBio Inc.","version":"1.0","type":"link"}