{"product_id":"spint1-polyclonal-antibody-bs8196","title":"SPINT1 Polyclonal Antibody-BS8196","description":"\u003cp\u003eSPINT1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS8196-50, BS8196-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O43278\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:2000\u003cbr\u003e\nIHC\/IF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Tissue damage, such as hepatic and renal injury, initiates hepatocyte growth factor activator (HGFAC)-mediated limited proteolytic activation of the inactive single-chain precursor form of HGF. Initially, HGFAC is produced as a precursor protein, which is activated by limited proteolysis and is neutralized by specific inhibitors known as HGF activator inhibitors, designated HAIs. HAIs belong to the Kunitz-type serine protease inhibitor family. HAIs target HGF activator and are involved in the regulation of proteolytic activation of HGF in injured tissues. Human HAI-1 transcript is expressed in various human tissues, such as adult placenta, kidney, pancreas, prostate and small intestine, and fetal kidney and lung. It translates into a 478 amino acid protein. The human HAI-2 gene maps to chromosome 19q13.1 and encodes a 252 amino acid protein, also designated human placental bikunin or kop (Kunitz domain containing protein over-expressed in pancreatic cancer). HAI-1 and HAI-2 are produced in membrane-associated forms, which are secreted as active, proteolytically truncated proteins.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: SPINT1 polyclonal antibody detects endogenous levels of SPINT1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 70 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of extracts of various cells, using SPINT1 antibody., Immunohistochemistry of paraffin-embedded human prostate using SPINT1 antibody at dilution of 1:100 (40x lens)., Immunohistochemistry of paraffin-embedded mouse esophageal cancer using SPINT1 antibody at dilution of 1:100 (40x lens).\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Kunitz-type protease inhibitor 1; Hepatocyte growth factor activator inhibitor type 1; HAI-1; SPINT1; HAI1; UNQ223\/PRO256\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant full length Human SPINT1.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42997576794291,"sku":"BS8196-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42997576827059,"sku":"BS8196-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e39fa921-a574-4862-a419-5cd2fdb103c1.jpg?v=1706270613","url":"https:\/\/afsbio.com\/products\/spint1-polyclonal-antibody-bs8196","provider":"AFSBio Inc.","version":"1.0","type":"link"}