{"product_id":"spop-polyclonal-antibody-bt-ap08515","title":"SPOP Polyclonal Antibody - BT-AP08515","description":"\u003cp\u003eSPOP Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP08515-20, BT-AP08515-50, BT-AP08515-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: SPOP (speckle type BTB\/POZ protein) encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1. , a variant H2A histone that is enriched on inactivated X chromosomes. The BTB\/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of SPOP results in multiple transcript variants encoding the same protein.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SPOP\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: SPOP Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 42132\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O43791; Mouse: Q6ZWS8\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 8405; Mouse: 20747\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239918264499,"sku":"BT-AP08515-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239918297267,"sku":"BT-AP08515-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239918330035,"sku":"BT-AP08515-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_3d3a59a7-f366-48e7-8973-d0c9f87c87e5.png?v=1769400904","url":"https:\/\/afsbio.com\/products\/spop-polyclonal-antibody-bt-ap08515","provider":"AFSBio Inc.","version":"1.0","type":"link"}