{"product_id":"sptc2-rabbit-polyclonal-antibody-es12972","title":"SPTC2 Rabbit Polyclonal Antibody - ES12972","description":"\u003cp\u003eSPTC2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES12972-50, ES12972-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human SPTC2 AA range: 273-323\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: SPTC2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of SPTC2 at Human\/Mouse\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.100% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widely expressed,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 60kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Sphingolipid metabolism, Metabolic pathways, Sphingolipid signaling pathway\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: Palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO(2)\u003cbr\u003e\nCofactor: Pyridoxal phosphate\u003cbr\u003e\nPathway: Lipid metabolism, sphingolipid metabolism\u003cbr\u003e\nSimilarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family\u003cbr\u003e\nSubunit: SPTLC1, SPTLC2 and SPTLC3 may encode subunits of the enzyme\u003cbr\u003e\nTissue Specificity: Widely expressed\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Endoplasmic reticulum membrane, Single-pass membrane protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: SPTLC2 KIAA0526 LCB2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: SPTC2\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 20773\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P97363\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314988634291,"sku":"ES12972-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314988667059,"sku":"ES12972-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/sptc2-rabbit-polyclonal-antibody-es12972","provider":"AFSBio Inc.","version":"1.0","type":"link"}