{"product_id":"sqstm1-mouse-monoclonal-antibody-mb9009","title":"SQSTM1 Mouse Monoclonal Antibody-MB9009","description":"\u003cp\u003eSQSTM1 Mouse Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB9009-50, MB9009-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q13501\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Monkey, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: FC, IHC, WB,\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB 1:500~2000\u003cbr\u003e\nIHC 1:150\u003cbr\u003e\nFLOW 1:100\u003c\/p\u003e\n\n\u003cp\u003eBackground: Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress and autophagy. It was first identified as a protein that binds to the SH2 domain of p56Lck and independently found to interact with PKCζ. SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome. Interaction between SQSTM1 and TRAF6 leads to the K63-linked polyubiquitination of TRAF6 and subsequent activation of the NF-κB pathway. It may play a role in titin\/TTN downstream signaling in muscle cells and regulate signaling cascades through ubiquitination. P62 may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A\/G).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of SQSTM1 and does not cross-react with related proteins.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 62 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of SQSTM1 Mouse mAb at 1:500 dilution, Immunohistochemical analysis of paraffin-embedded Human pancreas tissue using anti-SQSTM1 antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded Human thyroid tissue using anti-SQSTM1 antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded Human prostate tissue using anti-SQSTM1 antibody. Counter stained with hematoxylin.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Sequestosome-1; EBI3-associated protein of 60 kDa; EBIAP; p60; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62; SQSTM1; ORCA; OSIL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Full length human recombinant protein of human SQSTM1 (NP_003891) produced in HEK293T cell.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":43058776768691,"sku":"MB9009-50","price":276.71,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":43058776801459,"sku":"MB9009-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_06f46a23-2ff2-43b4-81f2-352dfa502cd3.jpg?v=1708172173","url":"https:\/\/afsbio.com\/products\/sqstm1-mouse-monoclonal-antibody-mb9009","provider":"AFSBio Inc.","version":"1.0","type":"link"}