{"product_id":"sr-2c-polyclonal-antibody-ra30024","title":"SR-2C Polyclonal Antibody - RA30024","description":"SR-2C Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA30024-50, RA30024-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: 5-hydroxytryptamine receptor 2C (HTR2C) Homo sapiens This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015],\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/5000. Not yet tested in other applications.\n\nAlternative Names: HTR2C; HTR1C; 5-hydroxytryptamine receptor 2C; 5-HT-2C; 5-HT2C; 5-HTR2C; 5-hydroxytryptamine receptor 1C; 5-HT-1C; 5-HT1C; Serotonin receptor 2C\n\nApplications: WB; IHC-p; IF\/ICC; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 3358\n\nProtein MW (KDa): 55\n\nSWISS: P28335\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45122419523763,"sku":"RA30024-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45122419556531,"sku":"RA30024-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5560a86f-4f64-430c-8796-d3c36eee1a95.png?v=1773348677","url":"https:\/\/afsbio.com\/products\/sr-2c-polyclonal-antibody-ra30024","provider":"AFSBio Inc.","version":"1.0","type":"link"}