{"product_id":"srpk2-polyclonal-antibody-e-ab-19091","title":"SRPK2 Polyclonal Antibody - E-AB-19091","description":"\u003cp\u003eSRPK2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-19091-60, E-AB-19091-120, E-AB-19091-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: SRPK2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Human serine kinase SRPK2 mRNA; complete cds; Serine kinase SRPK2; Serine\/arginine rich protein specific kinase 2; Serine\/arginine-rich protein-specific kinase 2; Serine\/threonine protein kinase SRPK2 ; SFRS protein kinase 2; SFRSK2 ; SR protein specific kinase 2; SR-protein-specific kinase 2; SRPK2; SRPK2; SRSF protein kinase 2 C-terminal\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P78362\u003c\/p\u003e\n\n\u003cp\u003eBackground: Serine\/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine\/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53\/TP53 phosphorylation thereby relieving the repressive effect of p53\/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23\/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.56 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fusion protein of human SRPK2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:100-1:300, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43130743521459,"sku":"E-AB-19091-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43130743554227,"sku":"E-AB-19091-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43130743586995,"sku":"E-AB-19091-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_3bf4b507-8ad3-49ec-8a34-58d70de34a89.png?v=1709812088","url":"https:\/\/afsbio.com\/products\/srpk2-polyclonal-antibody-e-ab-19091","provider":"AFSBio Inc.","version":"1.0","type":"link"}