{"product_id":"stat1-α-β-polyclonal-antibody-bs91284","title":"Stat1 α\/β Polyclonal Antibody-BS91284","description":"\u003cp\u003eStat1 α\/β Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91284-50, BS91284-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P42224\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC IHC FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000\u003cbr\u003e\nICC:1:200\u003cbr\u003e\nIHC:1:200,\u003cbr\u003e\nFC:1:100-1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. The phosphorylated STATs dimerize and associate with ISGF3G\/IRF-9 to form a complex termed ISGF3 transcription factor that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Peptide affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Stat1 α\/β polyclonal antibody detects endogenous levels of Stat1 α\/β protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 87 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of Stat-1α\/β on different cell lysates using anti-Stat-1α\/β antibody at 1\/500 dilution. \u003cbr\u003e\n Positive control: \u003cbr\u003e\n Lane 1: Hela \u003cbr\u003e\n Lane 2: NIH\/3T3 \u003cbr\u003e\n Lane 3: MCF-7, ICC staining Stat-1α\/β in HepG2 cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Stat-1, CANDF7, DKFZp686B04100, ISGF 3, ISGF3, OTTHUMP00000163552, OTTHUMP00000165046, OTTHUMP00000165047, OTTHUMP00000205845, Signal transducer and activator of transcription 1, Signal transducer and activator of transcription 1, 91kDa, Signal transducer and activator of transcription 1-alpha\/beta, Stat1, STAT1, STAT91, Transcription factor ISGF-3 components p91\/p84,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: peptide\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42984627372211,"sku":"BS91284-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42984627404979,"sku":"BS91284-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_45cb35bc-eeb7-4bea-90c7-9fab39f70032.jpg?v=1705919673","url":"https:\/\/afsbio.com\/products\/stat1-%ce%b1-%ce%b2-polyclonal-antibody-bs91284","provider":"AFSBio Inc.","version":"1.0","type":"link"}