{"product_id":"stat6-phospho-thr645-polyclonal-antibody-ra30137","title":"Stat6 (phospho Thr645) Polyclonal Antibody - RA30137","description":"\u003cp\u003eStat6 (phospho Thr645) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA30137-50, RA30137-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: signal transducer and activator of transcription 6 (STAT6) Homo sapiens The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1\/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunoprecipitation: 2-5 ug\/mg lysate. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: STAT6; Signal transducer and activator of transcription 6; IL-4 Stat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC-p; IF (paraffin section) ; IP; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 6778\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P42226\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45120365592755,"sku":"RA30137-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45120365625523,"sku":"RA30137-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_3ed0d9ea-3303-4a49-9c38-2a92d2600132.png?v=1773357769","url":"https:\/\/afsbio.com\/products\/stat6-phospho-thr645-polyclonal-antibody-ra30137","provider":"AFSBio Inc.","version":"1.0","type":"link"}