{"product_id":"stk3-polyclonal-antibody-bz16657","title":"STK3 Polyclonal Antibody-BZ16657","description":"\u003cp\u003eSTK3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BZ16657-50, BZ16657-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q13188\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSTK3 Polyclonal Antibody-BZ16657\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-P, IP,\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1\/500-1\/1000 IHC: 1\/50-1\/100 IP: 1\/20\u003c\/p\u003e\n\n\u003cp\u003eBackground: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3\/MST2 and STK4\/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1\/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1\/TAZ.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Affinity Purified\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: Calculated MW: 56 kDa; Observed MW: 56 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of STK3 in HeLaLysates using STK3 antibody., Immunohistochemistry analysis of paraffin-embedded Human kidney using STK3 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: STK3; Mess1; MST-2; MST2; Serine\/threonine kinase 3; KRS1; STE20-like kinase MST2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthesized peptide derived from human STK3\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42957324353715,"sku":"BZ16657-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42957324386483,"sku":"BZ16657-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_f7987967-86f4-43df-9b0b-ea2252c191c2.jpg?v=1705144867","url":"https:\/\/afsbio.com\/products\/stk3-polyclonal-antibody-bz16657","provider":"AFSBio Inc.","version":"1.0","type":"link"}