{"product_id":"stub1-polyclonal-antibody-bs91298","title":"STUB1 Polyclonal Antibody-BS91298","description":"\u003cp\u003eSTUB1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91298-50, BS91298-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9UNE7(Human) Q9WUD1(Mouse)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC IF, IHC, IP,  FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000-1:2,000\u003cbr\u003e\nICC:1:50-1:200\u003cbr\u003e\nIHC:1:50-1:200\u003cbr\u003e\nFC:1:50-1:100\u003cbr\u003e\nIP:1:10-1:50\u003c\/p\u003e\n\n\u003cp\u003eBackground: CHIP (carboxy terminus of HSP 70-interacting protein), also designated STIP1 homology and U-box containing protein 1, HSPABP2, NY-CO-7, SDCCAG7 and STUB1, is a cytoplasmic E3 ubiquitin ligase that influences protein ubiquitylation. CHIP interacts with Smad1\/Smad4 and blocks BMP signaling through the ubiquitin-mediated degradation of Smad proteins. CHIP controls both association of Hsp70\/Hsp90 chaperones with ErbB2 and down-regulation of ErbB2 induced by inhibitors of Hsp90. A 1.3-kb transcript is most abundant in striated muscle (heart and skeletal muscle), with lower expression in pancreas and brain.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: STUB1 polyclonal antibody detects endogenous levels of STUB1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 35 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of STUB1 on different lysates using anti-STUB1 antibody at 1\/2,000 dilution.\u003cbr\u003e\n Positive control:\u003cbr\u003e\n Lane 1: 293 \u003cbr\u003e\n Lane 2: MCF-7\u003cbr\u003e\n Lane 3: SK-Br-3 \u003cbr\u003e\n Lane 4: Mouse kidney, ICC staining STUB1 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: STUB1, CHIP, PP1131, Antigen NY CO 7, Antigen NY-CO-7, C terminus of Hsp70-interacting protein, Carboxy terminus of Hsp70 interacting protein, Carboxy terminus of Hsp70-interacting protein, Carboxy terminus of Hsp70p interacting protein, CHIP, CHIP, CLL associated antigen KW 8, CLL-associated antigen KW-8, E3 ubiquitin protein ligase CHIP, E3 ubiquitin-protein ligase CHIP, Heat shock protein A binding protein 2 (c terminal), HSPABP2, NY CO 7, PP1131, SDCCAG7, Serologically defined colon cancer antigen 7, STIP1 homology and U Box containing protein 1, STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase, STIP1 homology and U box-containing protein 1, STUB 1, STUB1, UBOX 1, UBOX1,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Recombinant protein within human STUB1 aa 1-200.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42987052499123,"sku":"BS91298-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42987052531891,"sku":"BS91298-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_1cbe8d4b-7d11-487e-8a4d-6dc202c1a7a4.jpg?v=1706007879","url":"https:\/\/afsbio.com\/products\/stub1-polyclonal-antibody-bs91298","provider":"AFSBio Inc.","version":"1.0","type":"link"}