{"product_id":"svil-polyclonal-antibody-bt-ap14601","title":"SVIL Polyclonal Antibody - BT-AP14601","description":"\u003cp\u003eSVIL Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14601-20, BT-AP14601-50, BT-AP14601-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and\/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cell biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SVIL\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Supervillin\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O95425; Mouse: Q8K4L3\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Supervillin;Archvillin;p205\/p250\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 6840\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239375986867,"sku":"BT-AP14601-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239376019635,"sku":"BT-AP14601-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239376052403,"sku":"BT-AP14601-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_35c22ae6-fecb-4f87-83e0-3906841f32c4.png?v=1769393632","url":"https:\/\/afsbio.com\/products\/svil-polyclonal-antibody-bt-ap14601","provider":"AFSBio Inc.","version":"1.0","type":"link"}