{"product_id":"swap-70-monoclonal-antibody-mb67240","title":"SWAP-70 Monoclonal Antibody-MB67240","description":"\u003cp\u003eSWAP-70 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB67240-50, MB67240-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9UH65\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003eBackground: SWAP70 is a Rac family guanine nucleotide exchange factor (GEF). It is highly expressed by activated B cells. Following B cell stimulation, SWAP70 has been observed to translocate from the cytoplasm to the nucleus, where it plays a role in class switching, as well as to the membrane, where it associates with the B cell receptor. SWAP70 also plays a role in migration of B cells and other immune cell types including dendritic cells, eosinophils, and mast cells. Mice deficient in both SWAP70 and a related protein, DEF6, develop lupus-like autoimmunity due to misregulation of IRF4 in B cells and T cells leading to increased IL21 production and responsiveness.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of SWAP-70 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of SWAP-70 expression in HL60 (A) whole cell lysates.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 70 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: KIAA0640; Switch-associated protein 70; SWAP-70\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human SWAP-70. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42906420314291,"sku":"MB67240-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42906420347059,"sku":"MB67240-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_94018c09-380a-4f4b-b0a3-57d80345b186.jpg?v=1702919274","url":"https:\/\/afsbio.com\/products\/swap-70-monoclonal-antibody-mb67240","provider":"AFSBio Inc.","version":"1.0","type":"link"}