{"product_id":"synuclein-pan-a19-polyclonal-antibody-bs1349","title":"Synuclein-Pan (A19) Polyclonal Antibody-BS1349","description":"\u003cp\u003eSynuclein-Pan (A19) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS1349-50, BS1349-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P37840\/O76070\/Q16143\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e \n\n\u003cp\u003eBackground: The synuclein family members, including α-synuclein (also designated NACP for non-β amyloid component) and β-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. α-synuclein is localized to neuronal cell bodies and synapses. α-synuclein was first identified as a component of Alzheimer’s disease amyloid plaques. Abnormal platelet function in Alzheimer’s disease has been demonstrated. During megakaryocytic differentiation α-synuclein was found to be up-regulated, while β-synuclein is down-regulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of α-synuclein has been found in patients with early onset Parkinson’s disease.\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Synuclein-pan (A19) polyclonal antibody detects endogenous levels of Synuclein-pan (α-synuclein, β-synuclein, γ-synuclein) protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of Synuclein (A19) pAb at 1:500 dilution\u003cbr\u003e\nLane 1: Panc1 whole cell lysate (40ug)\u003cbr\u003e\nLane 2: HEK293T whole cell lysate (40ug)\u003cbr\u003e\nLane 3: A549 whole cell lysate (40ug)\u003cbr\u003e\nLane 4: The Brain tissue lysate of Mouse (40ug)\u003cbr\u003e\nLane 5: The Brain tissue lysate of Rat (40ug), Immunohistochemistry (IHC) analyzes of Synuclein (A19) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 18 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Alpha-synuclein; α-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; NACP; PARK1; Beta-synuclein; SNCB; β-synuclein; synuclein-β; Gamma-synuclein; γ-synuclein; synuclein-γ; Breast cancer-specific gene 1 protein; Persyn; Synoretin; SR; SNCG; BCSG1; PERSYN; PRSN\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids N-terminus of 19-30 Synuclein-α.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42953209675955,"sku":"BS1349-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42953209708723,"sku":"BS1349-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_26918ab8-944f-4f73-9342-8a5f357fe893.jpg?v=1705056812","url":"https:\/\/afsbio.com\/products\/synuclein-pan-a19-polyclonal-antibody-bs1349","provider":"AFSBio Inc.","version":"1.0","type":"link"}