{"product_id":"tab1-monoclonal-antibody-ra12053","title":"TAB1 Monoclonal Antibody - RA12053","description":"\u003cp\u003eTAB1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA12053-50, RA12053-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: TGF-beta activated kinase 1 (MAP3K7) binding protein 1 (TAB1) Homo sapiens The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7\/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14\/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced tr\u003c\/p\u003e\n\n\u003cp\u003eCondition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat; Bovine; Dog; Pig\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 10454\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q15750\u003c\/p\u003e\n\n\u003cp\u003eSource: Mouse\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45118999560371,"sku":"RA12053-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45118999593139,"sku":"RA12053-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_74678428-ce43-4710-ba1c-34c1e11696d0.png?v=1773344083","url":"https:\/\/afsbio.com\/products\/tab1-monoclonal-antibody-ra12053","provider":"AFSBio Inc.","version":"1.0","type":"link"}