{"product_id":"tab3-polyclonal-antibody-bt-ap14707","title":"TAB3 Polyclonal Antibody - BT-AP14707","description":"\u003cp\u003eTAB3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14707-20, BT-AP14707-50, BT-AP14707-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2\/TAB2, forms a ternary complex with the protein kinase MAP3K7\/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7\/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Signal transduction; Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TAB3\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q8N5C8; Mouse: Q571K4\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3;Mitogen-activated protein kinase kinase kinase 7-interacting protein 3;NF-kappa-B-activating protein 1;TAK1-binding protein 3;TAB-3;TG\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 257397\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239379919027,"sku":"BT-AP14707-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239379951795,"sku":"BT-AP14707-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239379984563,"sku":"BT-AP14707-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_07858d84-9394-4ff1-9566-3a4ec753429c.png?v=1769393706","url":"https:\/\/afsbio.com\/products\/tab3-polyclonal-antibody-bt-ap14707","provider":"AFSBio Inc.","version":"1.0","type":"link"}