{"product_id":"tacc1-rabbit-polyclonal-antibody-es7329","title":"TACC1 Rabbit Polyclonal Antibody - ES7329","description":"\u003cp\u003eTACC1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES7329-50, ES7329-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: TACC1, KIAA1103, Transforming acidic coiled-coil-containing protein 1, Gastric cancer antigen Ga55, Taxin-1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human TACC1. AA range:11-60\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: TACC1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: TACC1 Polyclonal Antibody detects endogenous levels of TACC1 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Isoform 1, isoform 3 and isoform 5 are ubiquitous, Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer, Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues, Down-regulated in a subset of cases of breast cancer,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 87kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Alternative Products: Additional isoforms seem to exist,Developmental Stage: Expressed at high level during early embryogenesis\u003cbr\u003e\nFunction: Likely involved in the processes that promote cell division prior to the formation of differentiated tissues\u003cbr\u003e\nMiscellaneous: Down-regulated in a subset of cases of breast cancer\u003cbr\u003e\nPTM: Isoform 1 is heavily phosphorylated, isoform 6 is not. Phosphorylated upon DNA damage, probably by ATM or ATR\u003cbr\u003e\nSimilarity: Belongs to the TACC family\u003cbr\u003e\nSimilarity: Contains 2 SPAZ (Ser\/Pro-rich AZU-1) domains\u003cbr\u003e\nSubcellular Location: Nucleus during interphase. Weakly concentrated at centrosomes during mitosis\u003cbr\u003e\nSubunit: Interacts with KIAA0097\/CH-TOG and with the oncogenic transcription factor YEATS4. Interacts with the Aurora kinases A and B (STK6 and AURKB). Interacts with LSM7, TDRD7 and SNRPG. Interacts with GCN5L2 and PCAF\u003cbr\u003e\nTissue Specificity: Isoform 1, isoform 3 and isoform 5 a\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Midbody Nucleus during interphase Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis, [Isoform 5]: Membrane, Lipid-anchor, [Isoform 10]: Cytoplasm\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: TACC1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Transforming acidic coiled-coil-containing protein 1\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 320165\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q6Y685\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313710977203,"sku":"ES7329-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313711009971,"sku":"ES7329-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/tacc1-rabbit-polyclonal-antibody-es7329","provider":"AFSBio Inc.","version":"1.0","type":"link"}