{"product_id":"tak1-phospho-ser412-rabbit-polyclonal-antibody-bt-ap12948","title":"TAK1 (Phospho-Ser412) Rabbit Polyclonal Antibody - BT-AP12948","description":"\u003cp\u003eTAK1 (Phospho-Ser412) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP12948-20, BT-AP12948-50, BT-AP12948-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the serine\/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP)| and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1| this protein forms a kinase complex including TRAF6| MAP3K7P1\/TAB1 and MAP3K7P2\/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8\/JNK| MAP2K4\/MKK4| and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Immunology; Signal transduction; Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MAP3K7\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: TAK1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: O43318; Mouse: Q62073; Rat: P0C8E4\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TAK1;Ser412; Mitogen-activated protein kinase kinase kinase 7; EC 2.7.11.25; Transforming growth factor-beta-activated kinase 1; TGF-beta-activated kinase 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 6885; Mouse: 26409; Rat: 100910771\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239026385075,"sku":"BT-AP12948-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239026417843,"sku":"BT-AP12948-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239026450611,"sku":"BT-AP12948-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_96f64d0b-aadb-45d6-aee8-0d87ee85e6ce.png?v=1769388089","url":"https:\/\/afsbio.com\/products\/tak1-phospho-ser412-rabbit-polyclonal-antibody-bt-ap12948","provider":"AFSBio Inc.","version":"1.0","type":"link"}