{"product_id":"tal1-2-acetyl-lys221-acetyl-lys222-acetyl-lys36-acetyl-lys37-polyclonal-antibody-bt-ap01689","title":"TAL1\/2 (Acetyl Lys221\/Acetyl Lys222\/Acetyl Lys36\/Acetyl Lys37) Polyclonal Antibody - BT-AP01689","description":"\u003cp\u003eTAL1\/2 (Acetyl Lys221\/Acetyl Lys222\/Acetyl Lys36\/Acetyl Lys37) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP01689-20, BT-AP01689-50, BT-AP01689-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: alternative products:The splicing pattern is cell-lineage dependent|disease:A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.|The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.|Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.|PTM:Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.|PTM:Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122| ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells| since it could not be observed in large vessel endothelial cells.|Contains 1 basic helix-loop-helix (bHLH) domain.|subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3| LDB1| TAL1 and TCF3.|tissue specificity:Leukemic stem cell.|\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling; Developmental biology; Stem cells; Cancer; Cell biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TAL1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: T-cell acute lymphocytic leukemia protein 1 homolog\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P17542; Mouse: P22091\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: T-cell acute lymphocytic leukemia protein 1 homolog\/T-cell acute lymphocytic leukemia protein 2; TAL1; BHLHA17; SCL; TCL5; T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia\/lymphoma protein 5; TAL2; BHLHA19; T-cell acute lymphocytic leukemia protein 2; TAL-2; Class A basic helix-loop-helix protein 19; bHLHa19\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 6886; Mouse: 21349\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238978412723,"sku":"BT-AP01689-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238978445491,"sku":"BT-AP01689-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238978478259,"sku":"BT-AP01689-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c855a3b7-7f24-49a1-b328-3def2ed4661d.png?v=1769387484","url":"https:\/\/afsbio.com\/products\/tal1-2-acetyl-lys221-acetyl-lys222-acetyl-lys36-acetyl-lys37-polyclonal-antibody-bt-ap01689","provider":"AFSBio Inc.","version":"1.0","type":"link"}