{"product_id":"tal1-acetyl-k221-k222-polyclonal-antibody-bs64094","title":"TAL1 (Acetyl-K221\/K222) Polyclonal Antibody-BS64094","description":"\u003cp\u003eTAL1 (Acetyl-K221\/K222) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS64094-50, BS64094-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P17542\/Q16559\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Activation of TAL1 characterizes up to 60% ofcases of human T cell acute lymph oblastic leukemia,making it themost frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phospho protein and basic helixx-loop-helixtranscription factorknown to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB\/HTF4 to a nucleotide sequence motif termed the E-box.In addition, leukemogenesisis accelerated dramatically bytransgenic coexpression of TAL1 and the catalyticsubunit ofcasein kinase IIα, a serine\/threonine protein kinase known tomodulate the activity of other βHLH transcription factors.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: TAL1 (Acetyl-K221\/K222) polyclonal antibody detects endogenous levels of TAL1 protein only when acetylated at Lys221 and Lys222. This antibody also recognizes TAL2 protein when acetylated at Lys36 and Lys37.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 34 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western Blot (WB) analysis of TAL1 (Acetyl-K221\/K222) polyclonal antibody at 1:500 dilution\u003cbr\u003e\n Lane1:HEK293T whole cell lysate(40ug)\u003cbr\u003e\n Lane2:C6 whole cell lysate(40ug))\u003cbr\u003e\n Lane3:PC12 whole cell lysate(40ug)\u003cbr\u003e\n Lane4:MCF-7 whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia\/lymphoma protein 5; TAL1; T-cell acute lymphocytic leukemia protein 2; TAL-2; Class A basic helix-loop-helix protein 19; bHLHa19; TAL2\u003c\/p\u003e\n\n\n\u003cp\u003eImmunogen: Synthetic Acetylated peptide derived from human TAL1 around the Acetylation site of K221\/K222.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Acetylated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42923484971187,"sku":"BS64094-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42923485003955,"sku":"BS64094-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_78b23b3d-e20a-497a-9eb5-a416f3181bc9.jpg?v=1703850319","url":"https:\/\/afsbio.com\/products\/tal1-acetyl-k221-k222-polyclonal-antibody-bs64094","provider":"AFSBio Inc.","version":"1.0","type":"link"}