{"product_id":"task-1-rabbit-polyclonal-antibody-es8371","title":"TASK-1 Rabbit Polyclonal Antibody - ES8371","description":"\u003cp\u003eTASK-1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES8371-50, ES8371-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: KCNK3, TASK, TASK1, Potassium channel subfamily K member 3, Acid-sensitive potassium channel protein TASK-1, TWIK-related acid-sensitive K(+) channel 1, Two pore potassium channel KT3.1, Two pore K(+) channel KT3.1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human TASK-1. AA range:47-96\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: TASK-1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: TASK-1 Polyclonal Antibody detects endogenous levels of TASK-1 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widespread expression in adult, Strongest expression in pancreas and placenta, Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 53kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward\u003cbr\u003e\nMiscellaneous: Inhibited by external acidification. Activated by halothane and isoflurane\u003cbr\u003e\nSimilarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family\u003cbr\u003e\nTissue Specificity: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cell membrane, Multi-pass membrane protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: KCNK3\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Potassium channel subfamily K member 3\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 16527\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: O35111\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 29553\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: O54912\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313797583027,"sku":"ES8371-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313797615795,"sku":"ES8371-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/task-1-rabbit-polyclonal-antibody-es8371","provider":"AFSBio Inc.","version":"1.0","type":"link"}